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ZCCHC8 (Zinc finger CCHC domain-containing protein 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.
In plain words · ZCCHC8 (Zinc finger CCHC domain-containing protein 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
ZCCHC8 (Zinc finger CCHC domain-containing protein 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs.
No product in this corpus aims at ZCCHC8 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:25265 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6NZY4 (protein name, function text, keywords and locations (REST API)); IntOGen ZCCHC8 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function. Location: Nucleus, nucleoplasm; Nucleus (UniProt). Locus 12q24.31 (HGNC).
Query for this target: (TITLE:"ZCCHC8" OR ABSTRACT:"ZCCHC8" OR TITLE:"zinc finger CCHC-type containing 8" OR ABSTRACT:"zinc finger CCHC-type containing 8" OR TITLE:"Zinc finger CCHC domain-containing protein 8" OR ABSTRACT:"Zinc finger CCHC domain-containing protein 8" OR TITLE:"DKFZp434E2220" OR ABSTRACT:"DKFZp434E2220") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZCCHC8, not a curated reading list.