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ZBTB20 (Zinc finger and BTB domain-containing protein 20) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts.
May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Low-Grade Glioma, NOS.
In plain words · ZBTB20 (Zinc finger and BTB domain-containing protein 20) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts.
ZBTB20 (Zinc finger and BTB domain-containing protein 20) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts.
May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
No product in this corpus aims at ZBTB20 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2001. Earliest sequence paper UniProt cites for the protein: Zhang et al, Biochem. Biophys. Res. Commun, 2001, "Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6". Source.
Sources: HGNC HGNC:13503 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HC78 (protein name, function text, keywords and locations (REST API)); IntOGen ZBTB20 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal. Location: Nucleus (UniProt). Locus 3q13.31 (HGNC).
Query for this target: (TITLE:"ZBTB20" OR ABSTRACT:"ZBTB20" OR TITLE:"zinc finger and BTB domain containing 20" OR ABSTRACT:"zinc finger and BTB domain containing 20" OR TITLE:"Zinc finger and BTB domain-containing protein 20" OR ABSTRACT:"Zinc finger and BTB domain-containing protein 20" OR TITLE:"ODA-8S" OR ABSTRACT:"ODA-8S" OR TITLE:"DKFZp566F123" OR ABSTRACT:"DKFZp566F123" OR TITLE:"ZNF288" OR ABSTRACT:"ZNF288") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZBTB20, not a curated reading list.