Loading
VAV1 (Proto-oncogene vav) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.
In plain words · VAV1 (Proto-oncogene vav) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
VAV1 (Proto-oncogene vav) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Locus 19p13.3 (HGNC).
No product in this corpus aims at VAV1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1989. Earliest sequence paper UniProt cites for the protein: Katzav et al, EMBO J, 1989, "vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells". Source.
Sources: HGNC HGNC:12657 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15498 (protein name, function text, keywords and locations (REST API)); IntOGen VAV1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Locus 19p13.3 (HGNC).
Query for this target: (TITLE:"VAV1" OR ABSTRACT:"VAV1" OR TITLE:"vav guanine nucleotide exchange factor 1" OR ABSTRACT:"vav guanine nucleotide exchange factor 1" OR TITLE:"Proto-oncogene vav" OR ABSTRACT:"Proto-oncogene vav") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VAV1, not a curated reading list.
Shares HTLV-1, Tax and HBZ in adult T-cell leukaemia/lymphoma, Oncogenic viruses, Inflammation & NF-κB, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares HTLV-1, Tax and HBZ in adult T-cell leukaemia/lymphoma, Oncogenic viruses, Inflammation & NF-κB, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares HTLV-1, Tax and HBZ in adult T-cell leukaemia/lymphoma, Oncogenic viruses, Inflammation & NF-κB, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares HTLV-1, Tax and HBZ in adult T-cell leukaemia/lymphoma, Oncogenic viruses, Inflammation & NF-κB, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares HTLV-1, Tax and HBZ in adult T-cell leukaemia/lymphoma, Oncogenic viruses, Inflammation & NF-κB, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares Oncogenic viruses, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Inflammation & NF-κB, IntOGen, Non-Hodgkin lymphoma (all types), Non-small-cell lung cancer.