Loading
UBXN11 (UBX domain-containing protein 11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.
In plain words · UBXN11 (UBX domain-containing protein 11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
UBXN11 (UBX domain-containing protein 11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
No product in this corpus aims at UBXN11 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Cai et al, 2002. Source.
Sources: HGNC HGNC:30600 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5T124 (protein name, function text, keywords and locations (REST API)); IntOGen UBXN11 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1p36.11 (HGNC).
Query for this target: (TITLE:"UBXN11" OR ABSTRACT:"UBXN11" OR TITLE:"UBX domain protein 11" OR ABSTRACT:"UBX domain protein 11" OR TITLE:"UBX domain-containing protein 11" OR ABSTRACT:"UBX domain-containing protein 11" OR TITLE:"UBXD5" OR ABSTRACT:"UBXD5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about UBXN11, not a curated reading list.