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U2AF2 (Splicing factor U2AF 65 kDa subunit) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
In plain words · U2AF2 (Splicing factor U2AF 65 kDa subunit) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
U2AF2 (Splicing factor U2AF 65 kDa subunit) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing.
No product in this corpus aims at U2AF2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1992. Earliest sequence paper UniProt cites for the protein: Zamore P.D. et al, Nature, 1992, "Cloning and domain structure of the mammalian splicing factor U2AF". Source.
Sources: HGNC HGNC:23156 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P26368 (protein name, function text, keywords and locations (REST API)); IntOGen U2AF2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Location: Nucleus (UniProt). Locus 19q13.42 (HGNC).
Query for this target: (TITLE:"U2AF2" OR ABSTRACT:"U2AF2" OR TITLE:"U2 small nuclear RNA auxiliary factor 2" OR ABSTRACT:"U2 small nuclear RNA auxiliary factor 2" OR TITLE:"Splicing factor U2AF 65 kDa subunit" OR ABSTRACT:"Splicing factor U2AF 65 kDa subunit" OR TITLE:"U2AF65" OR ABSTRACT:"U2AF65") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about U2AF2, not a curated reading list.