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TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C".
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.
In plain words · TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C". Locus 11q14.3 (HGNC).
No product in this corpus aims at TRIM49C yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:38877 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0CI26 (protein name, function text, keywords and locations (REST API)); IntOGen TRIM49C (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C". Locus 11q14.3 (HGNC).
Query for this target: (TITLE:"TRIM49C" OR ABSTRACT:"TRIM49C" OR TITLE:"tripartite motif containing 49C" OR ABSTRACT:"tripartite motif containing 49C" OR TITLE:"Tripartite motif-containing protein 49C" OR ABSTRACT:"Tripartite motif-containing protein 49C" OR TITLE:"TRIM49L2" OR ABSTRACT:"TRIM49L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM49C, not a curated reading list.