Loading
TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Non-Small Cell Lung Cancer, Prostate Adenocarcinoma.
In plain words · TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.
TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release.
No product in this corpus aims at TFRC yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1984. Earliest sequence paper UniProt cites for the protein: Schneider et al, Nature, 1984, "Primary structure of human transferrin receptor deduced from the mRNA sequence". Source.
Sources: HGNC HGNC:11763 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02786 (protein name, function text, keywords and locations (REST API)); IntOGen TFRC (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary haemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Location: Cell membrane; Melanosome; Secreted (UniProt). Locus 3q29 (HGNC).
Query for this target: (TITLE:"TFRC" OR ABSTRACT:"TFRC" OR TITLE:"transferrin receptor" OR ABSTRACT:"transferrin receptor" OR TITLE:"Transferrin receptor protein 1" OR ABSTRACT:"Transferrin receptor protein 1" OR TITLE:"CD71" OR ABSTRACT:"CD71" OR TITLE:"TFR1" OR ABSTRACT:"TFR1" OR TITLE:"p90" OR ABSTRACT:"p90") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TFRC, not a curated reading list.