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TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
IntOGen calls it a driver in 2 cohorts (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Low-Grade Glioma, NOS.
In plain words · TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Transcriptional regulator. Involved in the initiation of neuronal differentiation.
No product in this corpus aims at TCF12 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1991. Earliest sequence paper UniProt cites for the protein: Zhang et al, Nucleic Acids Res, 1991, "HTF4: a new human helix-loop-helix protein". Source.
Sources: HGNC HGNC:11623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99081 (protein name, function text, keywords and locations (REST API)); IntOGen TCF12 (driver in 2 cohorts (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). May be involved in the functional network that regulates the development of the GnRH axis. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).
Query for this target: (TITLE:"TCF12" OR ABSTRACT:"TCF12" OR TITLE:"transcription factor 12" OR ABSTRACT:"transcription factor 12" OR TITLE:"Transcription factor 12" OR ABSTRACT:"Transcription factor 12" OR TITLE:"HTF4" OR ABSTRACT:"HTF4" OR TITLE:"HsT17266" OR ABSTRACT:"HsT17266" OR TITLE:"bHLHb20" OR ABSTRACT:"bHLHb20") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCF12, not a curated reading list.