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TAF1L (Transcription initiation factor TFIID subunit 1-like) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.
In plain words · TAF1L (Transcription initiation factor TFIID subunit 1-like) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
TAF1L (Transcription initiation factor TFIID subunit 1-like) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Location: Nucleus (UniProt).
No product in this corpus aims at TAF1L yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2002. Earliest sequence paper UniProt cites for the protein: Wang P.J. et al, Hum. Mol. Genet, 2002, "Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis". Source.
Sources: HGNC HGNC:18056 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IZX4 (protein name, function text, keywords and locations (REST API)); IntOGen TAF1L (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Location: Nucleus (UniProt). Locus 9p21.1 (HGNC).
Query for this target: (TITLE:"TAF1L" OR ABSTRACT:"TAF1L" OR TITLE:"TATA-box binding protein associated factor 1 like" OR ABSTRACT:"TATA-box binding protein associated factor 1 like" OR TITLE:"Transcription initiation factor TFIID subunit 1-like" OR ABSTRACT:"Transcription initiation factor TFIID subunit 1-like") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TAF1L, not a curated reading list.