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SUSD2 (Sushi domain-containing protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.
In plain words · SUSD2 (Sushi domain-containing protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
SUSD2 (Sushi domain-containing protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest.
No product in this corpus aims at SUSD2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1999. Earliest sequence paper UniProt cites for the protein: Dunham et al, Nature, 1999, "The DNA sequence of human chromosome 22". Source.
Sources: HGNC HGNC:30667 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UGT4 (protein name, function text, keywords and locations (REST API)); IntOGen SUSD2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis. Location: Cell membrane (UniProt). Locus 22q11.23 (HGNC).
Query for this target: (TITLE:"SUSD2" OR ABSTRACT:"SUSD2" OR TITLE:"sushi domain containing 2" OR ABSTRACT:"sushi domain containing 2" OR TITLE:"Sushi domain-containing protein 2" OR ABSTRACT:"Sushi domain-containing protein 2" OR TITLE:"BK65A6.2" OR ABSTRACT:"BK65A6.2" OR TITLE:"FLJ22778" OR ABSTRACT:"FLJ22778" OR TITLE:"W5C5" OR ABSTRACT:"W5C5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SUSD2, not a curated reading list.