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SOX17 (Transcription factor SOX-17) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.
In plain words · SOX17 (Transcription factor SOX-17) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
SOX17 (Transcription factor SOX-17) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'.
No product in this corpus aims at SOX17 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Katoh, Int. J. Mol. Med, 2002, "Molecular cloning and characterization of human SOX17". Source.
Sources: HGNC HGNC:18122 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H6I2 (protein name, function text, keywords and locations (REST API)); IntOGen SOX17 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signalling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Location: Nucleus (UniProt). Locus 8q11.23 (HGNC).
Query for this target: (TITLE:"SOX17" OR ABSTRACT:"SOX17" OR TITLE:"SRY-box transcription factor 17" OR ABSTRACT:"SRY-box transcription factor 17" OR TITLE:"Transcription factor SOX-17" OR ABSTRACT:"Transcription factor SOX-17") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SOX17, not a curated reading list.