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SMC1A (Structural maintenance of chromosomes protein 1A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
In plain words · SMC1A (Structural maintenance of chromosomes protein 1A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
SMC1A (Structural maintenance of chromosomes protein 1A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex.
No product in this corpus aims at SMC1A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1995. Earliest sequence paper UniProt cites for the protein: Rocques P.J. et al, Hum. Mol. Genet, 1995, "The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes". Source.
Sources: HGNC HGNC:11111 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14683 (protein name, function text, keywords and locations (REST API)); IntOGen SMC1A (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Location: Nucleus; Chromosome; Chromosome, centromere, kinetochore (UniProt). Locus Xp11.22 (HGNC).
Query for this target: (TITLE:"SMC1A" OR ABSTRACT:"SMC1A" OR TITLE:"structural maintenance of chromosomes 1A" OR ABSTRACT:"structural maintenance of chromosomes 1A" OR TITLE:"Structural maintenance of chromosomes protein 1A" OR ABSTRACT:"Structural maintenance of chromosomes protein 1A" OR TITLE:"DXS423E" OR ABSTRACT:"DXS423E" OR TITLE:"KIAA0178" OR ABSTRACT:"KIAA0178" OR TITLE:"SB1.8" OR ABSTRACT:"SB1.8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SMC1A, not a curated reading list.