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SDCBP (Syntenin-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signalling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalisation and degradation of TGFR1.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.
In plain words · SDCBP (Syntenin-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
SDCBP (Syntenin-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis.
No product in this corpus aims at SDCBP yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Lin J.J. et al, Mol. Cell. Differ, 1996, "Characterization of a novel melanoma differentiation associated gene, mda-9, that is down-regulated during terminal cell differentiation". Source.
Sources: HGNC HGNC:10662 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00560 (protein name, function text, keywords and locations (REST API)); IntOGen SDCBP (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signalling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalisation and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signalling components. Location: Cell junction, focal adhesion; Cell junction, adherens junction; Cell membrane; Endoplasmic reticulum membrane (UniProt). Locus 8q12.1 (HGNC).
Query for this target: (TITLE:"SDCBP" OR ABSTRACT:"SDCBP" OR TITLE:"syndecan binding protein" OR ABSTRACT:"syndecan binding protein" OR TITLE:"Syntenin-1" OR ABSTRACT:"Syntenin-1" OR TITLE:"MDA-9" OR ABSTRACT:"MDA-9" OR TITLE:"SDCBP1" OR ABSTRACT:"SDCBP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDCBP, not a curated reading list.