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RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.
In plain words · RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).
No product in this corpus aims at RRN3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2000. Earliest sequence paper UniProt cites for the protein: Bodem et al, EMBO Rep, 2000, "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p". Source.
Sources: HGNC HGNC:30346 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NYV6 (protein name, function text, keywords and locations (REST API)); IntOGen RRN3 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). Location: Nucleus, nucleolus (UniProt). Locus 16p13.11 (HGNC).
Query for this target: (TITLE:"RRN3" OR ABSTRACT:"RRN3" OR TITLE:"RNA polymerase I transcription factor RRN3" OR ABSTRACT:"RNA polymerase I transcription factor RRN3" OR TITLE:"RNA polymerase I-specific transcription initiation factor RRN3" OR ABSTRACT:"RNA polymerase I-specific transcription initiation factor RRN3" OR TITLE:"DKFZp566E104" OR ABSTRACT:"DKFZp566E104" OR TITLE:"TIF-IA" OR ABSTRACT:"TIF-IA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RRN3, not a curated reading list.