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RPS3A (Small ribosomal subunit protein eS1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.
In plain words · RPS3A (Small ribosomal subunit protein eS1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.
RPS3A (Small ribosomal subunit protein eS1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPS3A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1992. Earliest sequence paper UniProt cites for the protein: Metspalu et al, Gene, 1992, "Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein". Source.
Sources: HGNC HGNC:10421 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P61247 (protein name, function text, keywords and locations (REST API)); IntOGen RPS3A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May play a role during erythropoiesis through regulation of transcription factor DDIT3. Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 4q31.3 (HGNC).
Query for this target: (TITLE:"RPS3A" OR ABSTRACT:"RPS3A" OR TITLE:"ribosomal protein S3A" OR ABSTRACT:"ribosomal protein S3A" OR TITLE:"Small ribosomal subunit protein eS1" OR ABSTRACT:"Small ribosomal subunit protein eS1" OR TITLE:"S3A" OR ABSTRACT:"S3A" OR TITLE:"eS1" OR ABSTRACT:"eS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS3A, not a curated reading list.