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RGS7 (Regulator of G protein signalling 7) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Non-small-cell lung cancer and Melanoma.
GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signalling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis.
IntOGen calls it a driver in 6 cohorts (4 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Melanoma.
In plain words · RGS7 (Regulator of G protein signalling 7) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Non-small-cell lung cancer and Melanoma.
RGS7 (Regulator of G protein signalling 7) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Non-small-cell lung cancer and Melanoma.
GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signalling cascades.
No product in this corpus aims at RGS7 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Koelle M.R. et al, Cell, 1996, "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Source.
Sources: HGNC HGNC:10003 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49802 (protein name, function text, keywords and locations (REST API)); IntOGen RGS7 (driver in 6 cohorts (Act 4, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signalling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis. Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signalling. Location: Cytoplasm, cytosol; Cytoplasm; Cell membrane; Membrane (UniProt). Locus 1q43 (HGNC).
Query for this target: (TITLE:"RGS7" OR ABSTRACT:"RGS7" OR TITLE:"regulator of G protein signaling 7" OR ABSTRACT:"regulator of G protein signaling 7" OR TITLE:"Regulator of G protein signaling 7" OR ABSTRACT:"Regulator of G protein signaling 7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RGS7, not a curated reading list.