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RGPD3 (RanBP2-like and GRIP domain-containing protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-small-cell lung cancer and Melanoma.
UniProt has no function text for A6NKT7; HGNC names it "RANBP2 like and GRIP domain containing 3".
IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Melanoma.
In plain words · RGPD3 (RanBP2-like and GRIP domain-containing protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-small-cell lung cancer and Melanoma.
RGPD3 (RanBP2-like and GRIP domain-containing protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-small-cell lung cancer and Melanoma.
UniProt has no function text for A6NKT7; HGNC names it "RANBP2 like and GRIP domain containing 3". Locus 2q12.2 (HGNC).
No product in this corpus aims at RGPD3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2000. Earliest sequence paper UniProt cites for the protein: 2000. Source.
Sources: HGNC HGNC:32416 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NKT7 (protein name, function text, keywords and locations (REST API)); IntOGen RGPD3 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for A6NKT7; HGNC names it "RANBP2 like and GRIP domain containing 3". Locus 2q12.2 (HGNC).
Query for this target: (TITLE:"RGPD3" OR ABSTRACT:"RGPD3" OR TITLE:"RANBP2 like and GRIP domain containing 3" OR ABSTRACT:"RANBP2 like and GRIP domain containing 3" OR TITLE:"RanBP2-like and GRIP domain-containing protein 3" OR ABSTRACT:"RanBP2-like and GRIP domain-containing protein 3" OR TITLE:"RGP3" OR ABSTRACT:"RGP3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RGPD3, not a curated reading list.