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RBM39 (RNA-binding protein 39) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.
In plain words · RBM39 (RNA-binding protein 39) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
RBM39 (RNA-binding protein 39) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing.
No product in this corpus aims at RBM39 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1993. Earliest sequence paper UniProt cites for the protein: Imai et al, J. Clin. Invest, 1993, "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". Source.
Sources: HGNC HGNC:15923 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14498 (protein name, function text, keywords and locations (REST API)); IntOGen RBM39 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity. Location: Nucleus speckle (UniProt). Locus 20q11.22 (HGNC).
Query for this target: (TITLE:"RBM39" OR ABSTRACT:"RBM39" OR TITLE:"RNA binding motif protein 39" OR ABSTRACT:"RNA binding motif protein 39" OR TITLE:"RNA-binding protein 39" OR ABSTRACT:"RNA-binding protein 39" OR TITLE:"CC1.3" OR ABSTRACT:"CC1.3" OR TITLE:"HCC1" OR ABSTRACT:"HCC1" OR TITLE:"CAPER" OR ABSTRACT:"CAPER") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBM39, not a curated reading list.