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RASA2 (Ras GTPase-activating protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.
In plain words · RASA2 (Ras GTPase-activating protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.
RASA2 (Ras GTPase-activating protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
No product in this corpus aims at RASA2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Kobayashi et al, Gene, 1996, "Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization". Source.
Sources: HGNC HGNC:9872 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15283 (protein name, function text, keywords and locations (REST API)); IntOGen RASA2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). Location: Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 3q23 (HGNC).
Query for this target: (TITLE:"RASA2" OR ABSTRACT:"RASA2" OR TITLE:"RAS p21 protein activator 2" OR ABSTRACT:"RAS p21 protein activator 2" OR TITLE:"Ras GTPase-activating protein 2" OR ABSTRACT:"Ras GTPase-activating protein 2" OR TITLE:"GAP1M" OR ABSTRACT:"GAP1M") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RASA2, not a curated reading list.