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PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Mixed Germ Cell Tumour.
In plain words · PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.
PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Location: Nucleus (UniProt).
No product in this corpus aims at PTMA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1986. Earliest sequence paper UniProt cites for the protein: Eschenfeldt W.H. et al, Proc. Natl. Acad. Sci. U.S.A, 1986, "The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA". Source.
Sources: HGNC HGNC:9623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P06454 (protein name, function text, keywords and locations (REST API)); IntOGen PTMA (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Location: Nucleus (UniProt). Locus 2q37.1 (HGNC).
Query for this target: (TITLE:"PTMA" OR ABSTRACT:"PTMA" OR TITLE:"prothymosin alpha" OR ABSTRACT:"prothymosin alpha" OR TITLE:"Prothymosin alpha" OR ABSTRACT:"Prothymosin alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTMA, not a curated reading list.
Shares Testicular germ cell tumours, IntOGen.