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PSPC1 (Paraspeckle component 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.
In plain words · PSPC1 (Paraspeckle component 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
PSPC1 (Paraspeckle component 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers.
No product in this corpus aims at PSPC1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Fox A.H. et al, Curr. Biol, 2002, "Paraspeckles: a novel nuclear domain". Source.
Sources: HGNC HGNC:20320 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WXF1 (protein name, function text, keywords and locations (REST API)); IntOGen PSPC1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Location: Nucleus speckle; Nucleus, nucleolus; Nucleus matrix; Cytoplasm (UniProt). Locus 13q12.11 (HGNC).
Query for this target: (TITLE:"PSPC1" OR ABSTRACT:"PSPC1" OR TITLE:"paraspeckle component 1" OR ABSTRACT:"paraspeckle component 1" OR TITLE:"Paraspeckle component 1" OR ABSTRACT:"Paraspeckle component 1" OR TITLE:"PSP1" OR ABSTRACT:"PSP1" OR TITLE:"FLJ10955" OR ABSTRACT:"FLJ10955") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSPC1, not a curated reading list.