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PPP3CA (Protein phosphatase 3 catalytic subunit alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Stomach Adenocarcinoma.
In plain words · PPP3CA (Protein phosphatase 3 catalytic subunit alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
PPP3CA (Protein phosphatase 3 catalytic subunit alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif.
No product in this corpus aims at PPP3CA yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1993. Earliest sequence paper UniProt cites for the protein: Muramatsu et al, Biochim. Biophys. Acta, 1993, "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)". Source.
Sources: HGNC HGNC:9314 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q08209 (protein name, function text, keywords and locations (REST API)); IntOGen PPP3CA (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarisation, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. Dephosphorylates heat shock protein HSPB1. Location: Cytoplasm; Cell membrane; Cell membrane, sarcolemma; Cytoplasm, myofibril, sarcomere, Z line (UniProt). Locus 4q24 (HGNC).
Query for this target: (TITLE:"PPP3CA" OR ABSTRACT:"PPP3CA" OR TITLE:"protein phosphatase 3 catalytic subunit alpha" OR ABSTRACT:"protein phosphatase 3 catalytic subunit alpha" OR TITLE:"Protein phosphatase 3 catalytic subunit alpha" OR ABSTRACT:"Protein phosphatase 3 catalytic subunit alpha" OR TITLE:"CNA1" OR ABSTRACT:"CNA1" OR TITLE:"PPP2B" OR ABSTRACT:"PPP2B" OR TITLE:"CALNA" OR ABSTRACT:"CALNA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP3CA, not a curated reading list.