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PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.
In plain words · PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein.
No product in this corpus aims at PLXNC1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1998. Earliest sequence paper UniProt cites for the protein: Comeau M.R. et al, Immunity, 1998, "A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR". Source.
Sources: HGNC HGNC:9106 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60486 (protein name, function text, keywords and locations (REST API)); IntOGen PLXNC1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Location: Membrane (UniProt). Locus 12q22 (HGNC).
Query for this target: (TITLE:"PLXNC1" OR ABSTRACT:"PLXNC1" OR TITLE:"plexin C1" OR ABSTRACT:"plexin C1" OR TITLE:"Plexin-C1" OR ABSTRACT:"Plexin-C1" OR TITLE:"VESPR" OR ABSTRACT:"VESPR" OR TITLE:"CD232" OR ABSTRACT:"CD232") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLXNC1, not a curated reading list.