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PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction.
IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma, Lung Adenocarcinoma, Plasma Cell Myeloma.
In plain words · PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.
PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction.
No product in this corpus aims at PARP4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:271 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UKK3 (protein name, function text, keywords and locations (REST API)); IntOGen PARP4 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 13q12.12 (HGNC).
Query for this target: (TITLE:"PARP4" OR ABSTRACT:"PARP4" OR TITLE:"poly ADP-ribose polymerase family member 4" OR ABSTRACT:"poly ADP-ribose polymerase family member 4" OR TITLE:"Protein mono-ADP-ribosyltransferase PARP4" OR ABSTRACT:"Protein mono-ADP-ribosyltransferase PARP4" OR TITLE:"VAULT3" OR ABSTRACT:"VAULT3" OR TITLE:"p193" OR ABSTRACT:"p193" OR TITLE:"VPARP" OR ABSTRACT:"VPARP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PARP4, not a curated reading list.