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NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
In plain words · NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
No product in this corpus aims at NT5C3A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Rich S.A. et al, J. Biol. Chem, 1996, "Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions". Source.
Sources: HGNC HGNC:17820 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H0P0 (protein name, function text, keywords and locations (REST API)); IntOGen NT5C3A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. Location: Cytoplasm; Endoplasmic reticulum (UniProt). Locus 7p14.3 (HGNC).
Query for this target: (TITLE:"NT5C3A" OR ABSTRACT:"NT5C3A" OR TITLE:"5'-nucleotidase, cytosolic IIIA" OR ABSTRACT:"5'-nucleotidase, cytosolic IIIA" OR TITLE:"Cytosolic 5'-nucleotidase 3A" OR ABSTRACT:"Cytosolic 5'-nucleotidase 3A" OR TITLE:"UMPH1" OR ABSTRACT:"UMPH1" OR TITLE:"PSN1" OR ABSTRACT:"PSN1" OR TITLE:"PN-I" OR ABSTRACT:"PN-I") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NT5C3A, not a curated reading list.