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NRK (Nik-related protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Squamous Cell Carcinoma.
In plain words · NRK (Nik-related protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
NRK (Nik-related protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway.
No product in this corpus aims at NRK yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:25391 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z2Y5 (protein name, function text, keywords and locations (REST API)); IntOGen NRK (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway. Locus Xq22.3 (HGNC).
Query for this target: (TITLE:"NRK" OR ABSTRACT:"NRK" OR TITLE:"Nik related kinase" OR ABSTRACT:"Nik related kinase" OR TITLE:"Nik-related protein kinase" OR ABSTRACT:"Nik-related protein kinase" OR TITLE:"DKFZp686A17109" OR ABSTRACT:"DKFZp686A17109") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NRK, not a curated reading list.