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NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Endometrial Carcinoma.
In plain words · NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo.
No product in this corpus aims at NCKIPSD yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2000. Earliest sequence paper UniProt cites for the protein: Sano et al, Blood, 2000, "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)". Source.
Sources: HGNC HGNC:15486 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NZQ3 (protein name, function text, keywords and locations (REST API)); IntOGen NCKIPSD (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerisation and cell adhesion. Plays a role in angiogenesis. Location: Nucleus (UniProt). Locus 3p21.31 (HGNC).
Query for this target: (TITLE:"NCKIPSD" OR ABSTRACT:"NCKIPSD" OR TITLE:"NCK interacting protein with SH3 domain" OR ABSTRACT:"NCK interacting protein with SH3 domain" OR TITLE:"NCK-interacting protein with SH3 domain" OR ABSTRACT:"NCK-interacting protein with SH3 domain" OR TITLE:"AF3P21" OR ABSTRACT:"AF3P21" OR TITLE:"SPIN90" OR ABSTRACT:"SPIN90" OR TITLE:"ORF1" OR ABSTRACT:"ORF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCKIPSD, not a curated reading list.