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MUC6 (Mucin-6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Acute myeloid leukaemia and Non-small-cell lung cancer.
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumour markers in a variety of cancers. May play a role in epithelial organogenesis.
IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma.
In plain words · MUC6 (Mucin-6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Acute myeloid leukaemia and Non-small-cell lung cancer.
MUC6 (Mucin-6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Acute myeloid leukaemia and Non-small-cell lung cancer.
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen.
No product in this corpus aims at MUC6 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1993. Earliest sequence paper UniProt cites for the protein: Toribara N.W. et al, J. Biol. Chem, 1993, "Human gastric mucin. Identification of a unique species by expression cloning". Source.
Sources: HGNC HGNC:7517 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6W4X9 (protein name, function text, keywords and locations (REST API)); IntOGen MUC6 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumour markers in a variety of cancers. May play a role in epithelial organogenesis. Location: Secreted (UniProt). Locus 11p15.5 (HGNC).
Query for this target: (TITLE:"MUC6" OR ABSTRACT:"MUC6" OR TITLE:"mucin 6, oligomeric mucus/gel-forming gene/pseudogene" OR ABSTRACT:"mucin 6, oligomeric mucus/gel-forming gene/pseudogene" OR TITLE:"Mucin-6" OR ABSTRACT:"Mucin-6" OR TITLE:"MUC-6" OR ABSTRACT:"MUC-6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MUC6, not a curated reading list.