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MIB2 (E3 ubiquitin-protein ligase MIB2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signalling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.
In plain words · MIB2 (E3 ubiquitin-protein ligase MIB2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
MIB2 (E3 ubiquitin-protein ligase MIB2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins.
No product in this corpus aims at MIB2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2002. Earliest sequence paper UniProt cites for the protein: Takeuchi, 2002, "A novel zinc finger protein". Source.
Sources: HGNC HGNC:30577 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96AX9 (protein name, function text, keywords and locations (REST API)); IntOGen MIB2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signalling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Location: Cytoplasm; Endosome (UniProt). Locus 1p36.33 (HGNC).
Query for this target: (TITLE:"MIB2" OR ABSTRACT:"MIB2" OR TITLE:"MIB E3 ubiquitin protein ligase 2" OR ABSTRACT:"MIB E3 ubiquitin protein ligase 2" OR TITLE:"E3 ubiquitin-protein ligase MIB2" OR ABSTRACT:"E3 ubiquitin-protein ligase MIB2" OR TITLE:"skeletrophin" OR ABSTRACT:"skeletrophin" OR TITLE:"ZZZ5" OR ABSTRACT:"ZZZ5" OR TITLE:"FLJ39787" OR ABSTRACT:"FLJ39787") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MIB2, not a curated reading list.