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MED23 (Mediator of RNA polymerase II transcription subunit 23) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
In plain words · MED23 (Mediator of RNA polymerase II transcription subunit 23) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
MED23 (Mediator of RNA polymerase II transcription subunit 23) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.
No product in this corpus aims at MED23 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Rachez et al, Nature, 1999, "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Source.
Sources: HGNC HGNC:2372 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9ULK4 (protein name, function text, keywords and locations (REST API)); IntOGen MED23 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signalling. Location: Nucleus (UniProt). Locus 6q23.2 (HGNC).
Query for this target: (TITLE:"MED23" OR ABSTRACT:"MED23" OR TITLE:"mediator complex subunit 23" OR ABSTRACT:"mediator complex subunit 23" OR TITLE:"Mediator of RNA polymerase II transcription subunit 23" OR ABSTRACT:"Mediator of RNA polymerase II transcription subunit 23" OR TITLE:"CRSP130" OR ABSTRACT:"CRSP130" OR TITLE:"DRIP130" OR ABSTRACT:"DRIP130" OR TITLE:"Sur2" OR ABSTRACT:"Sur2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MED23, not a curated reading list.