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MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
May be involved in cell-cell interactions.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.
In plain words · MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
May be involved in cell-cell interactions. Location: Cell membrane (UniProt).
No product in this corpus aims at MDGA2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2003. Earliest sequence paper UniProt cites for the protein: Huang C.Q. et al, 2003. Source.
Sources: HGNC HGNC:19835 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z553 (protein name, function text, keywords and locations (REST API)); IntOGen MDGA2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be involved in cell-cell interactions. Location: Cell membrane (UniProt). Locus 14q21.3 (HGNC).
Query for this target: (TITLE:"MDGA2" OR ABSTRACT:"MDGA2" OR TITLE:"MAM domain containing glycosylphosphatidylinositol anchor 2" OR ABSTRACT:"MAM domain containing glycosylphosphatidylinositol anchor 2" OR TITLE:"MAM domain-containing glycosylphosphatidylinositol anchor protein 2" OR ABSTRACT:"MAM domain-containing glycosylphosphatidylinositol anchor protein 2" OR TITLE:"MAMDC1" OR ABSTRACT:"MAMDC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MDGA2, not a curated reading list.