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MCM7 (DNA replication licensing factor MCM7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer.
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Cervical Squamous Cell Carcinoma.
In plain words · MCM7 (DNA replication licensing factor MCM7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer.
MCM7 (DNA replication licensing factor MCM7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer.
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.
No product in this corpus aims at MCM7 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1993. Earliest sequence paper UniProt cites for the protein: Hu et al, Nucleic Acids Res, 1993, "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins". Source.
Sources: HGNC HGNC:6950 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P33993 (protein name, function text, keywords and locations (REST API)); IntOGen MCM7 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Location: Nucleus; Chromosome (UniProt). Locus 7q22.1 (HGNC).
Query for this target: (TITLE:"MCM7" OR ABSTRACT:"MCM7" OR TITLE:"minichromosome maintenance complex component 7" OR ABSTRACT:"minichromosome maintenance complex component 7" OR TITLE:"DNA replication licensing factor MCM7" OR ABSTRACT:"DNA replication licensing factor MCM7" OR TITLE:"CDC47" OR ABSTRACT:"CDC47" OR TITLE:"PPP1R104" OR ABSTRACT:"PPP1R104" OR TITLE:"MCM2" OR ABSTRACT:"MCM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MCM7, not a curated reading list.