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MARK2 (Serine/threonine-protein kinase MARK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
In plain words · MARK2 (Serine/threonine-protein kinase MARK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
MARK2 (Serine/threonine-protein kinase MARK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation.
No product in this corpus aims at MARK2 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1993. Earliest sequence paper UniProt cites for the protein: Schultz S.J. et al, Cell Growth Differ, 1993, "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Source.
Sources: HGNC HGNC:3332 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7KZI7 (protein name, function text, keywords and locations (REST API)); IntOGen MARK2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Location: Cell membrane; Cytoplasm; Lateral cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 11q13.1 (HGNC).
Query for this target: (TITLE:"MARK2" OR ABSTRACT:"MARK2" OR TITLE:"microtubule affinity regulating kinase 2" OR ABSTRACT:"microtubule affinity regulating kinase 2" OR TITLE:"Serine/threonine-protein kinase MARK2" OR ABSTRACT:"Serine/threonine-protein kinase MARK2" OR TITLE:"PAR-1" OR ABSTRACT:"PAR-1" OR TITLE:"Par1b" OR ABSTRACT:"Par1b" OR TITLE:"PAR-1B" OR ABSTRACT:"PAR-1B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MARK2, not a curated reading list.