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MACC1 (Metastasis-associated in colon cancer protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.
In plain words · MACC1 (Metastasis-associated in colon cancer protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
MACC1 (Metastasis-associated in colon cancer protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo.
No product in this corpus aims at MACC1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2003. Earliest sequence paper UniProt cites for the protein: Scherer S.W. et al, Science, 2003, "Human chromosome 7: DNA sequence and biology". Source.
Sources: HGNC HGNC:30215 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZN28 (protein name, function text, keywords and locations (REST API)); IntOGen MACC1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo. Location: Cytoplasm; Nucleus (UniProt). Locus 7p21.1 (HGNC).
Query for this target: (TITLE:"MACC1" OR ABSTRACT:"MACC1" OR TITLE:"MET transcriptional regulator MACC1" OR ABSTRACT:"MET transcriptional regulator MACC1" OR TITLE:"Metastasis-associated in colon cancer protein 1" OR ABSTRACT:"Metastasis-associated in colon cancer protein 1" OR TITLE:"7A5" OR ABSTRACT:"7A5" OR TITLE:"SH3BP4L" OR ABSTRACT:"SH3BP4L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MACC1, not a curated reading list.