Loading
LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.
In plain words · LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation.
No product in this corpus aims at LSM14A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2001. Earliest sequence paper UniProt cites for the protein: Takeda et al, 2001, "Possible alpha synuclein binding protein". Source.
Sources: HGNC HGNC:24489 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8ND56 (protein name, function text, keywords and locations (REST API)); IntOGen LSM14A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Location: Cytoplasm, P-body; Cytoplasm, cytoskeleton, spindle; Cytoplasm, Stress granule (UniProt). Locus 19q13.11 (HGNC).
Query for this target: (TITLE:"LSM14A" OR ABSTRACT:"LSM14A" OR TITLE:"LSM14A mRNA processing body assembly factor" OR ABSTRACT:"LSM14A mRNA processing body assembly factor" OR TITLE:"Protein LSM14 homolog A" OR ABSTRACT:"Protein LSM14 homolog A" OR TITLE:"DKFZP434D1335" OR ABSTRACT:"DKFZP434D1335" OR TITLE:"RAP55A" OR ABSTRACT:"RAP55A" OR TITLE:"RAP55" OR ABSTRACT:"RAP55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LSM14A, not a curated reading list.