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KNSTRN (Small kinetochore-associated protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cutaneous Melanoma.
In plain words · KNSTRN (Small kinetochore-associated protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
KNSTRN (Small kinetochore-associated protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase.
No product in this corpus aims at KNSTRN yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Touji et al, 1996. Source.
Sources: HGNC HGNC:30767 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y448 (protein name, function text, keywords and locations (REST API)); IntOGen KNSTRN (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidence. Location: Nucleus; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center (UniProt). Locus 15q15.1 (HGNC).
Query for this target: (TITLE:"KNSTRN" OR ABSTRACT:"KNSTRN" OR TITLE:"kinetochore localized astrin SPAG5 binding protein" OR ABSTRACT:"kinetochore localized astrin SPAG5 binding protein" OR TITLE:"Small kinetochore-associated protein" OR ABSTRACT:"Small kinetochore-associated protein" OR TITLE:"FLJ14502" OR ABSTRACT:"FLJ14502" OR TITLE:"kinastrin" OR ABSTRACT:"kinastrin" OR TITLE:"TRAF4AF1" OR ABSTRACT:"TRAF4AF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KNSTRN, not a curated reading list.