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KMT5A (N-lysine methyltransferase KMT5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Invasive Breast Carcinoma.
In plain words · KMT5A (N-lysine methyltransferase KMT5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
KMT5A (N-lysine methyltransferase KMT5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1).
No product in this corpus aims at KMT5A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2001. Earliest sequence paper UniProt cites for the protein: Tain et al, 2001, "A novel PR/SET domain-containing gene, SET07, as a candidate tumor suppressor". Source.
Sources: HGNC HGNC:29489 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQR1 (protein name, function text, keywords and locations (REST API)); IntOGen KMT5A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Location: Nucleus; Chromosome (UniProt). Locus 12q24.31 (HGNC).
Query for this target: (TITLE:"KMT5A" OR ABSTRACT:"KMT5A" OR TITLE:"lysine methyltransferase 5A" OR ABSTRACT:"lysine methyltransferase 5A" OR TITLE:"N-lysine methyltransferase KMT5A" OR ABSTRACT:"N-lysine methyltransferase KMT5A" OR TITLE:"SET8" OR ABSTRACT:"SET8" OR TITLE:"SET07" OR ABSTRACT:"SET07" OR TITLE:"PR-Set7" OR ABSTRACT:"PR-Set7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KMT5A, not a curated reading list.