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HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.
In plain words · HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
No product in this corpus aims at HSPG2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1989. Earliest sequence paper UniProt cites for the protein: Heremans et al, J. Cell Biol, 1989, "Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes". Source.
Sources: HGNC HGNC:5273 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98160 (protein name, function text, keywords and locations (REST API)); IntOGen HSPG2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularisation. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Location: Secreted, extracellular space, extracellular matrix, basement membrane; Secreted (UniProt). Locus 1p36.12 (HGNC).
Query for this target: (TITLE:"HSPG2" OR ABSTRACT:"HSPG2" OR TITLE:"heparan sulfate proteoglycan 2" OR ABSTRACT:"heparan sulfate proteoglycan 2" OR TITLE:"Basement membrane-specific heparan sulfate proteoglycan core protein" OR ABSTRACT:"Basement membrane-specific heparan sulfate proteoglycan core protein" OR TITLE:"perlecan" OR ABSTRACT:"perlecan" OR TITLE:"PRCAN" OR ABSTRACT:"PRCAN" OR TITLE:"SJS1" OR ABSTRACT:"SJS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSPG2, not a curated reading list.