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HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.
In plain words · HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.
No product in this corpus aims at HSP90AB1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1987. Earliest sequence paper UniProt cites for the protein: Rebbe N.F. et al, Gene, 1987, "Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family". Source.
Sources: HGNC HGNC:5258 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08238 (protein name, function text, keywords and locations (REST API)); IntOGen HSP90AB1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. Location: Cytoplasm; Melanosome; Nucleus; Secreted (UniProt). Locus 6p21.1 (HGNC).
Query for this target: (TITLE:"HSP90AB1" OR ABSTRACT:"HSP90AB1" OR TITLE:"heat shock protein 90 alpha family class B member 1" OR ABSTRACT:"heat shock protein 90 alpha family class B member 1" OR TITLE:"Heat shock protein HSP 90-beta" OR ABSTRACT:"Heat shock protein HSP 90-beta" OR TITLE:"HSPC2" OR ABSTRACT:"HSPC2" OR TITLE:"HSPCB" OR ABSTRACT:"HSPCB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSP90AB1, not a curated reading list.