Loading
GPAA1 (GPI-anchor transamidase component GPAA1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.
In plain words · GPAA1 (GPI-anchor transamidase component GPAA1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
GPAA1 (GPI-anchor transamidase component GPAA1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis.
No product in this corpus aims at GPAA1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Hiroi et al, FEBS Lett, 1998, "Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins". Source.
Sources: HGNC HGNC:4446 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43292 (protein name, function text, keywords and locations (REST API)); IntOGen GPAA1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor. Location: Endoplasmic reticulum membrane (UniProt). Locus 8q24.3 (HGNC).
Query for this target: (TITLE:"GPAA1" OR ABSTRACT:"GPAA1" OR TITLE:"glycosylphosphatidylinositol anchor attachment 1" OR ABSTRACT:"glycosylphosphatidylinositol anchor attachment 1" OR TITLE:"GPI-anchor transamidase component GPAA1" OR ABSTRACT:"GPI-anchor transamidase component GPAA1" OR TITLE:"GAA1" OR ABSTRACT:"GAA1" OR TITLE:"hGAA1" OR ABSTRACT:"hGAA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GPAA1, not a curated reading list.