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GMPS (GMP synthase [glutamine-hydrolysing]) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma.
Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.
In plain words · GMPS (GMP synthase [glutamine-hydrolysing]) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma.
GMPS (GMP synthase [glutamine-hydrolysing]) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma.
Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. Location: Cytoplasm, cytosol (UniProt).
No product in this corpus aims at GMPS yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1994. Earliest sequence paper UniProt cites for the protein: Hirst et al, J. Biol. Chem, 1994, "Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA". Source.
Sources: HGNC HGNC:4378 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49915 (protein name, function text, keywords and locations (REST API)); IntOGen GMPS (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. Location: Cytoplasm, cytosol (UniProt). Locus 3q25.31 (HGNC).
Query for this target: (TITLE:"GMPS" OR ABSTRACT:"GMPS" OR TITLE:"guanosine monophosphate synthase" OR ABSTRACT:"guanosine monophosphate synthase" OR TITLE:"GMP synthase [glutamine-hydrolyzing]" OR ABSTRACT:"GMP synthase [glutamine-hydrolyzing]" OR TITLE:"GATD7" OR ABSTRACT:"GATD7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GMPS, not a curated reading list.