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FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
May be a positive regulator of adipogenesis.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lymphoid Neoplasm.
In plain words · FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
May be a positive regulator of adipogenesis. Location: Membrane (UniProt).
No product in this corpus aims at FNDC3B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2002. Earliest sequence paper UniProt cites for the protein: Wang et al, 2002. Source.
Sources: HGNC HGNC:24670 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q53EP0 (protein name, function text, keywords and locations (REST API)); IntOGen FNDC3B (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be a positive regulator of adipogenesis. Location: Membrane (UniProt). Locus 3q26.31 (HGNC).
Query for this target: (TITLE:"FNDC3B" OR ABSTRACT:"FNDC3B" OR TITLE:"fibronectin type III domain containing 3B" OR ABSTRACT:"fibronectin type III domain containing 3B" OR TITLE:"Fibronectin type III domain-containing protein 3B" OR ABSTRACT:"Fibronectin type III domain-containing protein 3B" OR TITLE:"FAD104" OR ABSTRACT:"FAD104" OR TITLE:"DKFZp762K137" OR ABSTRACT:"DKFZp762K137" OR TITLE:"FLJ23399" OR ABSTRACT:"FLJ23399") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FNDC3B, not a curated reading list.