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FGD1 (FYVE, RhoGEF and PH domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.
In plain words · FGD1 (FYVE, RhoGEF and PH domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
FGD1 (FYVE, RhoGEF and PH domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
No product in this corpus aims at FGD1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1994. Earliest sequence paper UniProt cites for the protein: Pasteris N.G. et al, Cell, 1994, "Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor". Source.
Sources: HGNC HGNC:3663 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98174 (protein name, function text, keywords and locations (REST API)); IntOGen FGD1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Location: Cytoplasm; Cell projection, lamellipodium; Cell projection, ruffle; Cytoplasm, cytoskeleton (UniProt). Locus Xp11.22 (HGNC).
Query for this target: (TITLE:"FGD1" OR ABSTRACT:"FGD1" OR TITLE:"FYVE, RhoGEF and PH domain containing 1" OR ABSTRACT:"FYVE, RhoGEF and PH domain containing 1" OR TITLE:"FYVE, RhoGEF and PH domain-containing protein 1" OR ABSTRACT:"FYVE, RhoGEF and PH domain-containing protein 1" OR TITLE:"ZFYVE3" OR ABSTRACT:"ZFYVE3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGD1, not a curated reading list.