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FAT3 (Protocadherin Fat 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Pancreatic ductal adenocarcinoma, Renal cell carcinoma and 5 more.
May play a role in the interactions between neurites derived from specific subsets of neurons during development.
IntOGen calls it a driver in 29 cohorts (22 activating, 7 loss-of-function), covering Angiosarcoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Colon Adenocarcinoma and others.
In plain words · FAT3 (Protocadherin Fat 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Pancreatic ductal adenocarcinoma, Renal cell carcinoma and 5 more.
FAT3 (Protocadherin Fat 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Pancreatic ductal adenocarcinoma, Renal cell carcinoma and 5 more.
May play a role in the interactions between neurites derived from specific subsets of neurons during development. Location: Membrane (UniProt).
No product in this corpus aims at FAT3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Mitsui et al, Biochem. Biophys. Res. Commun, 2002, "Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs". Source.
Sources: HGNC HGNC:23112 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8TDW7 (protein name, function text, keywords and locations (REST API)); IntOGen FAT3 (driver in 29 cohorts (Act 22, LoF 7); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May play a role in the interactions between neurites derived from specific subsets of neurons during development. Location: Membrane (UniProt). Locus 11q14.3 (HGNC).
Query for this target: (TITLE:"FAT3" OR ABSTRACT:"FAT3" OR TITLE:"FAT atypical cadherin 3" OR ABSTRACT:"FAT atypical cadherin 3" OR TITLE:"Protocadherin Fat 3" OR ABSTRACT:"Protocadherin Fat 3" OR TITLE:"KIAA1989" OR ABSTRACT:"KIAA1989" OR TITLE:"CDHF15" OR ABSTRACT:"CDHF15" OR TITLE:"CDHR10" OR ABSTRACT:"CDHR10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAT3, not a curated reading list.