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DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.
UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2".
IntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Colon Adenocarcinoma, Glioblastoma Multiforme, Lung Adenocarcinoma, Prostate Adenocarcinoma.
In plain words · DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.
DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.
UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2". Locus Xq25 (HGNC).
No product in this corpus aims at DCAF12L2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:32950 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VW00 (protein name, function text, keywords and locations (REST API)); IntOGen DCAF12L2 (driver in 4 cohorts (Act 3, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2". Locus Xq25 (HGNC).
Query for this target: (TITLE:"DCAF12L2" OR ABSTRACT:"DCAF12L2" OR TITLE:"DDB1 and CUL4 associated factor 12 like 2" OR ABSTRACT:"DDB1 and CUL4 associated factor 12 like 2" OR TITLE:"DDB1- and CUL4-associated factor 12-like protein 2" OR ABSTRACT:"DDB1- and CUL4-associated factor 12-like protein 2" OR TITLE:"WDR40C" OR ABSTRACT:"WDR40C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DCAF12L2, not a curated reading list.