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CSPG4 (Chondroitin sulfate proteoglycan 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Invasive Breast Carcinoma.
In plain words · CSPG4 (Chondroitin sulfate proteoglycan 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
CSPG4 (Chondroitin sulfate proteoglycan 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration.
No product in this corpus aims at CSPG4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Pluschke et al, Proc. Natl. Acad. Sci. U.S.A, 1996, "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Source.
Sources: HGNC HGNC:2466 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6UVK1 (protein name, function text, keywords and locations (REST API)); IntOGen CSPG4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Location: Cell membrane; Apical cell membrane; Cell projection, lamellipodium membrane; Cell surface (UniProt). Locus 15q24.2 (HGNC).
Query for this target: (TITLE:"CSPG4" OR ABSTRACT:"CSPG4" OR TITLE:"chondroitin sulfate proteoglycan 4" OR ABSTRACT:"chondroitin sulfate proteoglycan 4" OR TITLE:"Chondroitin sulfate proteoglycan 4" OR ABSTRACT:"Chondroitin sulfate proteoglycan 4" OR TITLE:"MCSPG" OR ABSTRACT:"MCSPG" OR TITLE:"MEL-CSPG" OR ABSTRACT:"MEL-CSPG" OR TITLE:"MSK16" OR ABSTRACT:"MSK16") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSPG4, not a curated reading list.