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COL6A6 (Collagen alpha-6(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Collagen VI acts as a cell-binding protein.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
In plain words · COL6A6 (Collagen alpha-6(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
COL6A6 (Collagen alpha-6(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt).
No product in this corpus aims at COL6A6 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2006. Earliest sequence paper UniProt cites for the protein: Muzny D.M. et al, Nature, 2006, "The DNA sequence, annotation and analysis of human chromosome 3". Source.
Sources: HGNC HGNC:27023 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NMZ7 (protein name, function text, keywords and locations (REST API)); IntOGen COL6A6 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 3q22.1 (HGNC).
Query for this target: (TITLE:"COL6A6" OR ABSTRACT:"COL6A6" OR TITLE:"collagen type VI alpha 6 chain" OR ABSTRACT:"collagen type VI alpha 6 chain" OR TITLE:"Collagen alpha-6 VI chain" OR ABSTRACT:"Collagen alpha-6 VI chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about COL6A6, not a curated reading list.