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COL6A3 (Collagen alpha-3(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Melanoma.
Collagen VI acts as a cell-binding protein.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma. In OnCo, 1 product record names it (Vimseltinib).
In plain words · COL6A3 (Collagen alpha-3(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Melanoma.
COL6A3 (Collagen alpha-3(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Melanoma.
Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt).
No product in this corpus aims at COL6A3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
Tumour-associated overexpression: HPA finds the RNA tissue enhanced in normal smooth muscle, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA COL6A3: RNA tissue enhanced (smooth muscle 392 nTPM); no normal tissue stained high; highest cancer staining urothelial cancer (1 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 1 specific cancer type at or above 0.5 (Dupuytren Contracture). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas COL6A3 tissue; Human Protein Atlas COL6A3 pathology; Open Targets ENSG00000163359 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Chu M.-L. et al, Eur. J. Biochem, 1987, "Characterization of three constituent chains of collagen type VI by peptide sequences and cDNA clones". Source.
Sources: HGNC HGNC:2213 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12111 (protein name, function text, keywords and locations (REST API)); IntOGen COL6A3 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 2q37.3 (HGNC).
RNA: tissue enhanced (smooth muscle 392 nTPM), detected in many normal tissues.
No normal tissue stained high; medium in Bone marrow, Ovary, Skin.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"COL6A3" OR ABSTRACT:"COL6A3" OR TITLE:"collagen type VI alpha 3 chain" OR ABSTRACT:"collagen type VI alpha 3 chain" OR TITLE:"Collagen alpha-3 VI chain" OR ABSTRACT:"Collagen alpha-3 VI chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about COL6A3, not a curated reading list.