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CNOT9 (CCR4-NOT transcription complex subunit 9) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription.
IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Cutaneous Melanoma.
In plain words · CNOT9 (CCR4-NOT transcription complex subunit 9) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
CNOT9 (CCR4-NOT transcription complex subunit 9) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
No product in this corpus aims at CNOT9 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Okazaki et al, Mol. Cell. Biol, 1998, "Novel factor highly conserved among eukaryotes controls sexual development in fission yeast". Source.
Sources: HGNC HGNC:10445 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92600 (protein name, function text, keywords and locations (REST API)); IntOGen CNOT9 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Location: Nucleus; Cytoplasm, P-body (UniProt). Locus 2q35 (HGNC).
Query for this target: (TITLE:"CNOT9" OR ABSTRACT:"CNOT9" OR TITLE:"CCR4-NOT transcription complex subunit 9" OR ABSTRACT:"CCR4-NOT transcription complex subunit 9" OR TITLE:"RCD1" OR ABSTRACT:"RCD1" OR TITLE:"RCD1+" OR ABSTRACT:"RCD1+" OR TITLE:"CT129" OR ABSTRACT:"CT129" OR TITLE:"CAF40" OR ABSTRACT:"CAF40") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CNOT9, not a curated reading list.