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CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.
In plain words · CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.
No product in this corpus aims at CEP89 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:25907 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96ST8 (protein name, function text, keywords and locations (REST API)); IntOGen CEP89 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 19q13.11 (HGNC).
Query for this target: (TITLE:"CEP89" OR ABSTRACT:"CEP89" OR TITLE:"centrosomal protein 89" OR ABSTRACT:"centrosomal protein 89" OR TITLE:"Centrosomal protein of 89 kDa" OR ABSTRACT:"Centrosomal protein of 89 kDa" OR TITLE:"FLJ14640" OR ABSTRACT:"FLJ14640" OR TITLE:"CCDC123" OR ABSTRACT:"CCDC123") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CEP89, not a curated reading list.